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doi:10.1007/s00421-008-0911-7 Spriet, L

[26] For the first aerobic organisms, survival depended largely on their ability to defend against ROS

71 JonckheereA

Numerous mechanisms 15 have been proposed, including mechanical injury caused by severe motion of the basilar membrane, metabolic exhaustion of activated cells, activity-induced vascular narrowing that causes ischemia, and ionic poisoning from interruption of the normal chemical gradients of the cochlea owing to minuscule disruptions in the organization of sensory and supporting cells