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This RI value tends to zero in two cases: first, when the overall similarity between the tested compound and the most similar compounds used for the correction of the global model is weak, and second when an inconsistent variability between the predicted and experimental values was observed among the most similar compounds to the tested compound

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While VAL2240 and ASP2195 are the important amino acids of the crystal structures of MTOR, particularly in the kinase domain (Fig

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