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The concept of direct GH action on glomerular cells is supported by studies in transgenic mice overexpressing human or bovine GH showing progressive glomerulosclerosis, whereas IGF-1 overexpressing mice lack glomerular changes [14]

Figure 1 2 Basic concepts and pathological mechanisms of COPD 2.1 Definition and classification of COPD COPD is defined as a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities, usually caused by significant exposure to noxious particles or gases ( 2.2 Pathogenesis of COPD The pathogenesis of COPD is multifactorial and involves complicated interactions between environmental factors, immune responses, and genetic susceptibility ( While the pathogenesis of COPD is well-established to involve chronic inflammation, oxidative stress, and airway remodeling, current therapeutic strategies remain insufficient to halt disease progression

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Baldwin CM, Bootzin RR, Schwenke DC, Quan SF