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The AR promoter had reduced accessibility as early as 5 days of SPA, which persisted at 26 days (Figure 5G), consistent with prior reports indicating that ligand-bound AR exhibits negative autoregulation at the level of AR gene transcription (31)

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The Impact of Hormones, Medication, and Environmental Factors on Tear Osmolarity Hormones (cortisol, aldosterone, thyroid hormones, etc.), medications (antihistamines, beta-blockers, diuretics, isotretinoin, anti-cholinergics, etc.), and environmental factors all affect tear osmolarity and regulate tear-dependent eye protection