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This modification compacts chromatin, preventing transcription factors from binding

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readers should consult the current electronic Medicines Compendium (emc) SmPC and NICE appraisal guidance for the most up-to-date commissioning status

doi: 10.1038/s41598-024-58064-0 3 ArmaniniDBoscaroMBordinLSabbadinC

Multiple types of antagonists of IGF-1 have been studied including small-molecule tyrosine kinase inhibitors (TKIs) and competitive antagonists such as monoclonal antibodies directed against the IGF-1R or the use of IGF-1 peptide analogs (Table 2)