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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Pontarin G, Fijolek A, Pizzo P, Ferraro P, Rampazzo C, Pozzan T, Thelander L, Reichard PA, Bianchi V

doi: 10.1177/03000605221082898 6 PatilNRehmanAAnastasopoulouCJialalI

& Bardazzi, F

Studies indicate: Enhanced transcription of growth hormone messenger RNA in somatotrophs Increased pituitary growth hormone synthesis and storage capacity Preservation of somatotroph cell populations during aging Maintenance of pituitary reserve capacity with chronic administration This transcriptional effect distinguishes sermorelin from compounds that merely trigger release of existing hormone stores without supporting sustained pituitary function

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I