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In weight-dependent heterosynaptic plasticity, the direction and magnitude of synaptic changes depend on the initial strength of the synapse

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Moreover, GHK has been shown to be a quencher for hydroxyl and peroxyl radicals by ESR spectroscopy, with its ability to quench hydroxyl radicals much stronger than glutathione (GSH), making it a strong endogenous antioxidant [20]

It was suggested that this outcome was due to the peptide's apparent action of converting the enzymes from their active state to inactive state, as the total synthase levels appeared to remain at constant concentrations