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Metformin, which is well-tolerated due to extensive clinical experience in diabetes management, has shown promising epidemiological associations with reduced cancer incidence and improved outcomes in some studies

In the context of radiotherapy, hypoxic tumor cells exhibit increased resistance due to their impaired ability to produce damaging oxygen radicals upon irradiation (94)

Mobile phase A and B was 0.2% (v/v) AA in water (Optima grade, Fisher Scientific, USA) and 0.2% (v/v) AA in LC-MS grade acetonitrile (Honeywell, USA), respectively

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