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ScienceDirect , Journal of Affective Disorders , vol

Oxidized Grx1 is reduced only by GSH, while Grx2 can be reactivated using either glutathione or thioredoxin reductase, which suggests that this protein exhibits properties of both Grx and Trx [46] and implies the connection between the metabolic pathways controlled by glutathione and thioredoxin in mitochondria