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The precise regulation of LM, including gene expression, enzyme activity, and metabolite feedback inhibition, ensures metabolic homeostasis under different physiological conditions

For example, the iron-containing moiety lactotransferrin was more than 10-fold more abundant in middle ear effusions collected from children with chronic OM than haemoglobin (Val et al., 2016)

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In present study, oxidative stress was also assessed by measuring the antioxidant level and significant increased oxidative stress was observed

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