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PBN therapeutic strategies for cardiovascular inflammation encompass three key approaches: (1) Time-window precision leverages the temporal synchrony between platelet activation and inflammatory onset (e.g., post-acute type A aortic dissection surgery) to administer antiplatelet nanotherapeutics within defined intervention windows (e.g., 2 h), maximizing therapeutic efficacy [124]

Expression of HSP70 family members is triggered during stress or injury, including infections, increased oxidative stress and cytokines

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In most cases, the addition of GSSG to proteins renders them inactive, but for specific proteins such as heat shock proteins or peroxiredoxin 6, it may serve as an activation mechanism or a cell signaling event [3, 4]

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