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As we indicated in the FY 2007 IPPS rulemaking (71 FR 47894-95) when initially adopting a charges-to-cost methodology, no payment methodology can be perfect because DRG-specific costs cannot be determined

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By month fifteen, the trial's primary endpoint, the average participant had lost 15.2 percent of their starting weight, and the curve had become essentially horizontal [Garvey et al., Nature Medicine, 2022]