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It is now investigating at least five external doctors allegedly used to obtain prescriptions for peptides - among allegations of ''doctor shopping'' - for Essendon players to determine whether they actually physically examined them

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PMID 26683192

These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

[DOI] [PubMed] [Google Scholar] 86.Munzel T., Gori T., Keaney J.F., Jr., Maack C., Daiber A