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Optimization of these technological challenges, including means to either mechanically or biologically bypass the BBB, achieve sufficient antibody levels in CNS to enable adequate target engagement, and direct elimination only against aggregated -syn species, are needed to further evaluate important implications for future therapeutics

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Shrestha D.B., Budhathoki P., Sedhai Y.R., Adhikari A., Poudel A., Aryal B., Baniya R

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