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In Krabbe disease, triple combination therapyCNS-directed AAV9 gene therapy, hematopoietic stem cell transplantation, and small molecule substrate reduction therapy (L-cycloserine)extended the median lifespan from approximately 40 days in untreated mice to approximately 400 days, compared to 269 days with dual therapy alone

Thus, showing susceptibility of Gram-positive bacteria and lack of resistance, even among drug resistant isolates

The determination of Se status throughout experiments and self-medication of patients is very important for clarification of outcomes

D., Nunez, J

doi: 10.1056/NEJMoa1012985 [DOI] [PubMed] [Google Scholar] 14

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