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Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K

The diseases symptoms start to show up when 50%60% of dopaminergic neurons have been destroyed and dopamine levels in the striatum have dropped by about 80%85%

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R-GSSG activity is influenced by time since disease detection, age, sex, survival, length of hospitalization, and severity of disease course in approximately 18% of cases