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Endogenous nonprotein antioxidants Four well-known main antioxidant mechanisms against oxidative damage have been largely studied (1) sequestration of transition metal ions, (2) scavenging and quenching of ROS and RNS, (3) ending of chain reactions by free radicals, and (4) molecular repairing of radicals damages

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Mitochondria are essential organelles, whose dysfunction is central to major diseases 13,14 , as they are the center for aerobic ATP generation from oxidative phosphorylation (Oxphos) in the electron transport chain (ETC)

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More studies using specific NOX inhibitors or small molecules are therefore required to examine this possibility in more detail

Oncogene 38:301316 Kamei Y, Hattori M, Hatazawa Y, Kasahara T, Kanou M, Kanai S, Yuan X, Suganami T, Lamers WH, Kitamura T, Ogawa Y et al (2014) FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3-UTR: possible contribution to ammonia detoxification