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Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions

Errichi BM, Belcaro G, Hosoi M, et al

Vitamin B12 Overdose This article was reviewed by Kelly Brown MD, MBA Vitamin B12 overdose is so rare that serious adverse effects from consuming large amounts of vitamin B12 have only been reported in a handful of studies in the medical literature

However, caution is advised in individuals with diabetes, heart failure, or kidney disease, as some drinks contain sugars and electrolytes that may not be appropriate

Vitamin B12 injections reduce the risk of some serious complications that are associated with Vitamin B12 deficiency

It is possible that NNMT alters histone and DNA methylation status, inducing epigenetic remodeling and metabolism reprogramming (88)