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CrossRef Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci International Journal of Molecular Sciences.2022

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In Ang II-induced HUVECs, GA inhibited Extracellular Signal-Regulated Kinase (ERK) phosphorylation, Cyclophilin D (CypD) expression, the interaction of NOX4 and Poldip 2, and lowered mitochondrial ROS levels, resulting in an increase in the mitochondrial membrane potential of the HUVECs cells, thereby alleviating endothelial mitochondrial dysfunction (Sun et al., 2023)

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doi:10.1016/j.etap.2012.03.007 Okouchi M, Okayama N, Aw T (2005) Hyperglycemia potentiates carbonyl stress-induced apoptosis in naive PC-12 cells: relationship to cellular redox and activator protease factor-1 expression

The treatment should be administered slowly to tolerance to minimize potential side effects