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To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

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Central Nervous System Research Applications Standard rodent CNS protocols include middle cerebral artery occlusion (stroke model), controlled cortical impact (traumatic brain injury), cuprizone feeding (demyelination), and spinal cord compression

S., Pronyaeva, V

Side effects can depend on the research model, study design, and conditions being evaluated

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