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Using metabolic labeling with [ 32 P] and different mutants at the C terminal tail, the group of Law demonstrated that rat MOR (rMOR) displays a basal phosphorylation at S363 and T370 and DAMGO increases phosphorylation at T370 and S375 (El Kouhen et al., 2013) but failed to phosphorylate T370 (Doll et al., Phosphorylation studies using liquid chromatography-mass spectrometry techniques have led to the characterization of two regions at the C terminal tail of the MOR (Lau et al., 2011): the first region (amino acid 349365) can be mono- or bi-phosphorylated at S363 and in the cluster 354TSST357

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GST enzyme activity enhanced significantly in response to heat, cold, salt, and oxidative stresses as compared with their untreated (0 h) sample (Fig

Deleting or inhibiting the Group I mGluRs in rodents is associated with a reduction in learning and memory-associated tasks such as the Morris water maze task, which was the first evidence for the function of mGluR5 receptors in spatial learning using mGluR5 receptor knock-out animals [29]

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