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doi: 10.1038/s41598-021-93003-3 58 ZhangHKongWZhaoXXieYLuoDChenS

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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

Peripheral artery disease Peripheral artery disease (PAD) is a complete or partial occlusion of the peripheral artery in the limb by an atherosclerosis plaque

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Hold a 1- to 2-inch fold of skin between your fingers, then insert the needle at a 90-degree angle into the subcutaneous fat, ensuring it does not go too deep