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Genistein inhibits VEGF augmented secretion and activity of MMP-2 and MMP-9 [186] (Table 2)

Al though it lacks heme, it contains Fe2+ and tetrahydrobiopterin as cofactors used in the synthesis of dihydroxyphenylalanine (DOPA)

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It has been observed in humans that a more severe degree of NMDA receptor dysfunction is present in the AD brain than in those of age-matched controls (Ulas and Cotman, 1997)

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