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The COVID-19 pandemic, as highlighted by various epidemiological studies, exacerbated the global gap in PN management

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Abnormal trajectory: expanding redness beyond 3cm diameter, increasing warmth, new onset of pain after initial comfort, or lymphatic streaking (red lines extending from the site toward the trunk)

Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment

Vitamin B12 plays a vital role in red blood cell production, nerve function, and cellular energy

Patients at low-risk for fracture should be considered for drug discontinuation after 3 to 5 years of use