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There was a significant effect of voxel (ACC, SMA, OCC), a significant effect of group (OCD vs HV), and a trend for the group and voxel interaction

Using the constructed evolutionary tree combined with the TimeTree database (www.timetrees.org) and the literature, we obtained time correction points

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Future investigations utilizing targeted mechanistic interventions and causal experimental approaches (e.g., specific pathway inhibitors or genetic models) are warranted to clarify direct cause-and-effect relationships

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