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Basis for their potential use as coadjuvants in anticancer therapy

While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

Hence, we reasoned that Cys uptake may counteract ferroptosis not only through the well-established CysGSHGPX4 axis but also by enabling biosynthesis of S 0 species

The authors would like to thank Dr Pueschel for reviewing a draft of the article and for his helpful suggestions

Methods: PBC patients followed in a tertiary hepatology Italian centre with available quantitative AMA-M2 values were included in a cross-sectional analysis