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doi: 10.1096/fj.12-220509 241 ScolaAMJohswichKOMorganBPKlosAMonkPN

Nature 493 (7432), 346355

The Antifolates

doi: 10.1093/annonc/mdv026

The large amount of lactate that is produced is then excreted extracellularly to participate in the formation of the acidic TME, which contributes to the enhancement of immunosuppression and leads to worse clinical outcomes