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Elesclomol Induces Copper-Dependent Ferroptosis in Colorectal Cancer Cells via Degradation of ATP7A

In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103

Additionally, excess Cu-iron is essential for the execution of ferroptosis

Intravenous infusions have many therapeutic benefits but should not replace any treatment advised by your medical practitioner

Springer, New York, pp 2132 Lucas GNC, Leito ACC, Alencar RL, Xavier RMF, Daher EDF, Silva Junior GBD (2019) Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

As the OD value of the standard curve may vary according to the conditions of the actual assay performance (e.g operator, pipetting technique or temperature effects), so the standard curve and data are provided as below for reference only