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doi: 10.1186/s13046-021-02031-4 140 GongYFanZLuoGYangCHuangQFanKet al

That gastric origin explains its well-documented gastroprotective properties, but what has truly captured the research communitys attention is how far beyond the gut its apparent effects extend

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422 Additional therapeutic candidates have encountered unique translational challenges

Conclusion: While a significant increase in Ybx1 expression in differentiating preadipocytes may support healthy adipogenesis, our findings reveal a detrimental mechanism in which the maladaptive activation of Ybx1 within hepatocytes directly stimulates the C/EBP:PPAR pathway, leading to an increase in adipogenic gene expression that becomes lipotoxic within the liver