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Over time, this sustained resistance leads to pulmonary hypertension and subsequent right ventricular failure, known as cor pulmonale

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In pancreatic regeneration, sEVs activate the PDX-1 signaling axis to promote -cell regeneration and insulin secretion (Mahdipour et al., 2019)

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Since idebenone is a potent antioxidant, this finding suggests that loss of ISP activity in vivo is due chiefly to increased oxidative degradation, and not to impaired synthesis, of these proteins