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Cationic carriers can include, but are not limited to, polyethyleneimine, poly (trimethylene imine), poly (tetramethylene imine), polypropyleneimine, aminoglycoside-polyamine, dideoxy-diamino-b-cyclodextrin, spermine, spermidine, poly (2-dimethylamino) ethyl methacrylate, poly (lysine), poly (histidine), poly (arginine), cationized gelatin, dendrimers, chitosan, 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP), N- [1- (2, 3-dioleoyloxy) propyl ] -N, N, N-trimethylammonium chloride (DOTMA), 1- [2- (oleoyloxy) ethyl ] -2-oleyl-3- (2-hydroxyethyl) imidazolium chloride (DOTIM), 2, 3-dioleyloxy-N- [2 (spermicarbonamido) ethyl ] -N, N-dimethyl-1-propanaminium trifluoroacetate (DOSPA), 3B- [ N- (N ', N' -dimethylaminoethane) -carbamoyl ] cholesterol hydrochloride (DC-cholesterol HCl), di-heptadecylamido glycyl argininate (DOGS), N-distearyl-N, N-dimethylammonium bromide (DDAB), N- (1, 2-dimyristoyloxyprop-3-yl) -N, N-dimethyl N-hydroxyethylammonium bromide (DMRIE), N-dioleyl-N, N-dimethylammonium chloride (DODAC), and combinations thereof

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(2021) showed that AC diminished the learning and cognitive impairment induced by intracerebroventricular (ICV) injection of streptozotozin (STZ) in rodents to induce AD like symptoms

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However, targeting efficiency, biocompatibility, and clearance remain pivotal challenges in design of new MRI contrast agents