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The fact that, like these women [10, 13, 81], the mouse model had smaller ovarian reserves, later pubertal onset and possibly lower ovulatory rates, and that this gene encodes a widely-expressed steroidogenic enzyme with key roles in the HPG axis, led us to hypothesize that the SRD5A1 downregulation might mediate the effect of the early-life events on these characteristics, and the mouse model enabled us to examine its role in the central control of reproduction in vitro and in vivo

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Dutasteride is a 5-alpha-reductase inhibitor (5-ARI) indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) as monotherapy or in combination with tamsulosin

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