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HMGB1 expression is high in many cancer cells, especially in colon cancer, breast cancer, cervical cancer, lung cancer, prostate cancer, and pancreatic cancer 3-6

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451,452 Activation of mTORC1 by tumor-derived lactate leads to TFEB retention in the cytoplasm, which in turn decreases the expression of the macrophage-specific vacuolar ATPase subunit ATP6V0d2, which is required for lysosomal-mediated degradation of hypoxia-induced factor 2 (HIF-2)

(Fentanyl is increasingly being smoked in some places.) But Ciccarone thinks the evidence doesnt support this happening at a large scale

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