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Once the endogenous antioxidant efficiency is insufficient to maintain the reductionoxidation homeostasis, the exogenous antioxidants play an important role in inhibiting oxidative stress

, Chronic peroxisome proliferator-activated receptor/ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity, J

Certain subgroups may be more likely to respond to treatment, including those with lower methionine levels and/or lower GSH redox status

The high expression of RICTOR will induce mTORC2-AKT-C-MYC activation that upregulates GS expression