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Obesity and insulin resistance are associated with endothelial dysfunction, sympathetic nervous system hyperactivity, and hyperleptinaemia, all of which can lead to hypertension

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If these appear, reduce tirzepatide dose, pause 5-amino-1MQ, and increase caloric intake by 200400 kcal daily until symptoms resolve

While the connection exists, doctors usually investigate more common causes first, including poor nutrition, medication use, pernicious anemia, or digestive disorders like Crohns disease

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