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10.1016/j.preteyeres.2020.100849 35 MeiT.WuJ.WuK.ZhaoM.LuoJ.LiuX.et al (2022)

model AUC=0.826) were strongly associated with higher risk of decompensation, after adjusting for age, sex, race, primary liver disease, BMI, and Child-Pugh score

doi: 10.1016/j.exer.2025.110656 171 YangZYanYWangLZouGLuL

On the other hand, it has been shown that 2-hydroxyestrogen can damage DNA and generate free radicals when they go through redox cycling or when COMT is inhibited [38]

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Therefore, activating this pathway may allow SARS-CoV-2 to evade immunity