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2000;115:962968. doi:10.1046/j.1523-1747.2000.00166.x

Emerging epigenetic evidencederived predominantly from experimental animal modelssuggests that prolonged or repeated exposure to supraphysiological doses of anabolicandrogenic steroids may induce persistent molecular alterations in the male reproductive system

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doi: 10.3390/pr9020356 34 HanH.XingJ.ChenW.JiaJ.LiQ

Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling (Sun et al., 2018)

Key mediators in this pathological process are free radicals, which target the polyunsaturated fatty acids of the lens and initiate cataract formation [11]