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The GG genotype lowers homocysteine but raises risk for: Systemic lupus erythematosus Bipolar disorder Schizophrenia Congenital facial and spinal malformations Down syndrome Methionine Synthase Reductase: An AG substitution at base pair 66 affects ~ 30% of individuals

Glucose, insulin, homeostatic model assessment for insulin resistance, glutathione peroxidase, superoxide dismutase, oxidized LDL, and malondialdehyde did not significantly change after 4 weeks in any group

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When assessing information about any treatment, consider the quality of the underlying clinical evidence rather than individual reported experiences, and seek a face-to-face consultation with a qualified doctor before making any decisions

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Overall, 112 female participants received either the HCP ( n = 57) at 10 g per day or placebo ( n = 55) for 8 weeks