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The exogenous pathway consists of the activation of cell membrane transporters for transferrin (TF) and lactoferrin (LF) or the inhibition of cystine/glutamate (CySS/Glu) antiporters, while the endogenous pathway is the inhibition of GPX4 activation within cells (Li J

Another crucial challenge is the BBB penetration

10.1016/j.redox.2020.101679 119 PaddenbergR.StiegerP.von LilienA.-L.FaulhammerP.GoldenbergA.TillmannsH

However, an increase in mutation frequency above a critical threshold (usually 60%80%) leads to pathogenicity and mitochondrial disease manifestations (18, 19)

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Control of ascorbate peroxidase 2 expression by hydrogen peroxide and leaf water status during excess light stress reveals a functional organisation of Arabidopsis leaves