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A balanced translocation between chromosomes 14 and 21 in a parent can lead to offspring with translocation Down syndrome

Animal models are used as they can fill the gap that in vitro models often have, viz, the lack of physiological resemblance

Moret-Tatay I, Iborra M, Cerrillo E, Tortosa L, Nos P, Beltran B

Current DSIP research appears to be dominated by preclinical, mechanistic, and exploratory work rather than large modern human outcome trials [2]

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Those conversations between her and her patients, Mandeville said, rely heavily on scientific evidence thats available on whats safe to do during pregnancy, and what is not