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Ikemoto et al., 1997

On the other hand, ferroptosis, a unique form of non-apoptotic cell death, can be initiated by the accumulation of iron and production of reactive oxygen species (ROS) from lipid peroxidation [31]

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Heme oxygenase-1 (HO-1), a target gene of nuclear factor erythroid 2-related factor 2 (Nrf2), exhibits cellular protective effects through its antioxidant properties when moderately expressed, while also catalyzing the breakdown of heme to produce biliverdin, CO, and iron ions [21]

2017 May 1;32(5):870-879