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Progranulin inhibits LPS-induced macrophage M1 polarization via NF-B and MAPK pathways

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Metformin (ARROW LAB) was administered orally at 400 mg/kg/day (BID)

However, it is critical to understand that these peptides are not FDA-approved for any indication

Future research is warranted to address these challenges and investigate the possibility of synergizing inhibitors of NADPH synthesis for novel combinatorial therapies with current chemotherapeutics