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Even beginner SARMs like Ostarine (MK-2866) can cause suppression after just 4 weeks More aggressive SARMs like RAD-140, S23, and YK-11 are highly suppressive , requiring a full PCT protocol Without PCT, users risk prolonged hypogonadism, estrogen imbalance, depression, and muscle catabolism PCT should include a SERM (Selective Estrogen Receptor Modulator) such as Clomid or Nolvadex, typically run for 4 weeks Although SARMs are not aromatized into estrogen, they still suppress endogenous testosterone