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Impaired BBB integrity Postmortem studies of AD patients and animal models have revealed cellular infiltration, including red blood cells [139], macrophages [140], and neutrophils [141], as well as capillary leakage of blood-derived components such as fibrin(ogen), IgG, albumin, thrombin, and hemosiderin [142,143,144,145]

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Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid- aggregation

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This is desirable when a substantially non-fluid or substantially viscous formulation is needed

In the chronic phase, activated microglia are located in the peri-infarct region and distal areas, but generally the greatest amount of microglia peaks in the early stages (216)