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Patients should report severe or persistent injection site reactions, as these may indicate hypersensitivity or anaphylaxis requiring immediate medical attention

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The absence of resistance induction upon KEAP1 inhibition in SCLC cells was unexpected, given that ROS-induced inactivation or genetic loss of KEAP1 is a common mechanism of resistance to redox-targeting drugs in many cancer types 27

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Research in cell culture and animal models indicates that rapidly dividing cancer cells have a high requirement for thiamin (94)