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10.1681/ASN.2010070705 90 KlapanK.SimonD.KaraulovA.GomzikovaM.RizvanovA.YousefiS.et al (2022)

In adipocytes, TST positively correlates with insulin receptor substrate 1 (IRS1) levels and enhances adiponectin secretion, a key adipokine that promotes insulin sensitivity [87]

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

PD patients are subjected to nutritional disorders and deficiency of certain vitamins like folate, vitamin B6 and B12

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The clinical implications of these findings are substantial, and suggest that targeting GM through FMT and other microbiome-modulating therapies like prebiotics and probiotics may not only alleviate GI symptoms associated with PD but also enhance SCFAs, and anti-inflammatory cytokines (IL-6, IL-10) production, while decreasing pro-inflammatory cytokines and chemokines (MCP-1 and IL-8) (163)