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10.1186/s13075-018-1699-4 102 MisawaK.HasegawaT.MishimaE.JutabhaP.OuchiM.KojimaK.et al (2020)

A competitive inhibitor traps LeuT in an open-to-out conformation

That is how many years separate the 2014 Nature paper that put NNMT inhibition on the map [3] from wherever you are reading this in 2026

10.1371/journal.pone.0043602 12 BoscoA.InmanD

Cell Death Dis 9 , 753 (2018)

296 The presence of mutHTT and the accumulation of mtDNA mutations caused by inadequate mitophagy and decreased biogenesis impair oxidative phosphorylation, enhance the formation of reactive ROS, and lower ATP production