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Development and optimisation of alternative methods and approaches Main gaps identified: high rate of misleading/false genotoxic positives Existing in vitro methods, whilst having a high sensitivity (and thus low false negative rate), have a relatively low specificity and thus high rate of false (misleading) positive results, which typically has led to unnecessary follow-up testing in vivo for the confirmation of these results

Shen C, Lu Y, Zhang B, Figueiredo D, Bean J, Jung J, et al

After testing the biochemical parameters of each organ, organ indices were calculated and histomorphological changes were monitored

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If a sample screens positive for a prohibited substance or method, the lab will always perform robust and targeted confirmation procedures using the A sample

The complexity and variety of botanical drug constituents can impact the stability and efficacy of nanoparticles in clinical applications (Wei et al., 2022)