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Mitochondrial dysfunction leads to cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances and endothelial dysfunction, which all could play a role in long COVID

Among these, the MTHFR C677T variant has been most extensively studied, although findings from individual studies remain inconclusive, possibly due to underpowered cohorts [89, 90]

doi: 10.3748/wjg.v20.i37.13343

Since cPMP replacement therapy can only benefit MocoD Type A, additional treatment methods are required

Future studies should focus on identifying its active constituents, elucidating detailed mechanisms of action, and validating its efficacy in well-designed clinical trials

doi: 10.1016/j.rbmo.2019.12.005 57 ZhangHYangKChenFLiuQNiJCaoWet al