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doi: 10.1016/B978-0-444-64181-6.00013-9 211

After 1 h of administration, the total radioactivity peaked in most tissues, and the average concentration in the kidney was the highest, reaching 560 ng (Eq

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Synthetic antioxidants provide targeted support, while natural oxidants, derived from plant sources, contribute to a holistic and sustainable therapeutic strategy since they are used within regulations parameters (197)

Complementing these pharmacological findings, genetic approaches using Hv1 knockout, knockdown, and overexpression models demonstrated that Hv1 loss attenuates NF-Bmediated cytokine production and PI3K/Akt/HIF-1dependent glycolytic reprogramming in microglia in a LPS-induced hippocampal neuroinflammation model ( Collectively, these findings emphasize Hv1 involvement in demyelinating diseases and neuroinflammation